Jungle Honey Enhances Immune Function and Antitumor Activity
Joint Authors
Pinkerton, Kent E.
Fukuda, Miki
Takeuchi, Minoru
Ishida, Takahiro
Ejiogu, Emenike C.
Sawai, Masaharu
Hirono, Yuriko
Miyagawa, Mayuko
Kobayashi, Kengo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Jungle honey (JH) is collected from timber and blossom by wild honey bees that live in the tropical forest of Nigeria.
JH is used as a traditional medicine for colds, skin inflammation and burn wounds as well as general health care.
However, the effects of JH on immune functions are not clearly known.
Therefore, we investigated the effects of JH on immune functions and antitumor activity in mice.
Female C57BL/6 mice were injected with JH (1 mg/mouse/day, seven times intra-peritoneal).
After seven injections, peritoneal cells (PC) were obtained.
Antitumor activity was assessed by growth of Lewis Lung Carcinoma/2 (LL/2) cells.
PC numbers were increased in JH-injected mice compared to control mice.
In Dot Plot analysis by FACS, a new cell population appeared in JH-injected mice.
The percent of Gr-1 surface antigen and the intensity of Gr-1 antigen expression of PC were increased in JH-injected mice.
The new cell population was neutrophils.
JH possessed chemotactic activity for neutrophils.
Tumor incidence and weight were decreased in JH-injected mice.
The ratio of reactive oxygen species (ROS) producing cells was increased in JH-injected mice.
The effective component in JH was fractionized by gel filtration using HPLC and had an approximate molecular weight (MW) of 261.
These results suggest that neutrophils induced by JH possess potent antitumor activity mediated by ROS and the effective immune component of JH is substrate of MW 261.
American Psychological Association (APA)
Fukuda, Miki& Kobayashi, Kengo& Hirono, Yuriko& Miyagawa, Mayuko& Ishida, Takahiro& Ejiogu, Emenike C.…[et al.]. 2010. Jungle Honey Enhances Immune Function and Antitumor Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507264
Modern Language Association (MLA)
Fukuda, Miki…[et al.]. Jungle Honey Enhances Immune Function and Antitumor Activity. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-507264
American Medical Association (AMA)
Fukuda, Miki& Kobayashi, Kengo& Hirono, Yuriko& Miyagawa, Mayuko& Ishida, Takahiro& Ejiogu, Emenike C.…[et al.]. Jungle Honey Enhances Immune Function and Antitumor Activity. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507264