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Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome : A Review of Antiplatelet Therapy
Joint Authors
Marshall, Sally M.
Zaman, Azfar G.
Balasubramaniam, Karthik
Viswanathan, Girish N.
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-05
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Patients with diabetes mellitus presenting with acute coronary syndrome have a higher risk of cardiovascular complications and recurrent ischemic events when compared to nondiabetic counterparts.
Different mechanisms including endothelial dysfunction, platelet hyperactivity, and abnormalities in coagulation and fibrinolysis have been implicated for this increased atherothrombotic risk.
Platelets play an important role in atherogenesis and its thrombotic complications in diabetic patients with acute coronary syndrome.
Hence, potent platelet inhibition is of paramount importance in order to optimise outcomes of diabetic patients with acute coronary syndrome.
The aim of this paper is to provide an overview of the increased thrombotic burden in diabetes and acute coronary syndrome, the underlying pathophysiology focussing on endothelial and platelet abnormalities, currently available antiplatelet therapies, their benefits and limitations in diabetic patients, and to describe potential future therapeutic strategies to overcome these limitations.
American Psychological Association (APA)
Balasubramaniam, Karthik& Viswanathan, Girish N.& Marshall, Sally M.& Zaman, Azfar G.. 2012. Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome : A Review of Antiplatelet Therapy. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-507284
Modern Language Association (MLA)
Balasubramaniam, Karthik…[et al.]. Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome : A Review of Antiplatelet Therapy. Cardiology Research and Practice No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-507284
American Medical Association (AMA)
Balasubramaniam, Karthik& Viswanathan, Girish N.& Marshall, Sally M.& Zaman, Azfar G.. Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome : A Review of Antiplatelet Therapy. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-507284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507284