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Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator : Emerging Insights and Therapeutic Potential
Joint Authors
Nakamura, Toshikazu
Mizuno, Shinya
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sepsis-induced multiple organ failure (MOF) is the most frequent lethal disease in intensive care units.
Thus, it is important to elucidate the self-defensive mechanisms of sepsis-induced MOF.
Hepatocyte growth factor (HGF) is now recognized as an organotrophic factor, which is essential for organogenesis during embryonic growth and regeneration in adulthood.
HGF production is enhanced in response to infectious challenges, but the increase in endogenous HGF levels is transient and insufficient, with a time lag between tissue injuries and HGF upregulation, during progression of septic MOF.
Thus, administration of active-formed HGF might be a new candidate for therapeutic development of MOF.
HGF has an ability to target endotoxin-challenged macrophages and inhibits the upregulation of inflammatory cytokines through nuclear factor-κB-inactivated mechanisms.
HGF also targets the endothelium and epithelium of various organs to suppress local inflammation, coagulation, and apoptotic death.
This paper summarizes the novel mechanisms of HGF for attenuating sepsis-related pathological conditions with a focus on sepsis-induced MOF.
American Psychological Association (APA)
Mizuno, Shinya& Nakamura, Toshikazu. 2012. Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator : Emerging Insights and Therapeutic Potential. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-507307
Modern Language Association (MLA)
Mizuno, Shinya& Nakamura, Toshikazu. Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator : Emerging Insights and Therapeutic Potential. Gastroenterology Research and Practice No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-507307
American Medical Association (AMA)
Mizuno, Shinya& Nakamura, Toshikazu. Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator : Emerging Insights and Therapeutic Potential. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-507307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507307