Benzoyl Peroxide Formulated PolycarbophilCarbopol 934P Hydrogel with Selective Antimicrobial Activity, Potentially Beneficial for Treatment and Prevention of Bacterial Vaginosis
Joint Authors
Rogers, Michael A.
Cavera, Veronica L.
Zubovskiy, Konstantin
Huang, Qingrong
Chikindas, Michael L.
Xu, Shiqi
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The human vagina is colonized by a variety of indigenous microflora; in healthy individuals the predominant bacterial genus is Lactobacillus while those with bacterial vaginosis (BV) carry a variety of anaerobic representatives of the phylum Actinobacteria.
In this study, we evaluated the antimicrobial activity of benzoyl peroxide (BPO) encapsulated in a hydrogel against Gardnerella vaginalis, one of the causative agents of BV, as well as indicating its safety for healthy human lactobacilli.
Herein, it is shown that in well diffusion assays G.
vaginalis is inhibited at 0.01% hydrogel-encapsulated BPO and that the tested Lactobacillus spp.
can tolerate concentrations of BPO up to 2.5%.
In direct contact assays (cells grown in a liquid culture containing hydrogel with 1% BPO or BPO particles), we demonstrated that hydrogels loaded with 1% BPO caused 6-log reduction of G.
vaginalis.
Conversely, three of the tested Lactobacillus spp.
were not inhibited while L.
acidophilus growth was slightly delayed.
The rheological properties of the hydrogel formulation were probed using oscillation frequency sweep, oscillation shear stress sweep, and shear rate sweep.
This shows the gel to be suitable for vaginal application and that the encapsulation of BPO did not alter rheological properties.
American Psychological Association (APA)
Xu, Shiqi& Cavera, Veronica L.& Rogers, Michael A.& Huang, Qingrong& Zubovskiy, Konstantin& Chikindas, Michael L.. 2013. Benzoyl Peroxide Formulated PolycarbophilCarbopol 934P Hydrogel with Selective Antimicrobial Activity, Potentially Beneficial for Treatment and Prevention of Bacterial Vaginosis. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-507308
Modern Language Association (MLA)
Xu, Shiqi…[et al.]. Benzoyl Peroxide Formulated PolycarbophilCarbopol 934P Hydrogel with Selective Antimicrobial Activity, Potentially Beneficial for Treatment and Prevention of Bacterial Vaginosis. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-507308
American Medical Association (AMA)
Xu, Shiqi& Cavera, Veronica L.& Rogers, Michael A.& Huang, Qingrong& Zubovskiy, Konstantin& Chikindas, Michael L.. Benzoyl Peroxide Formulated PolycarbophilCarbopol 934P Hydrogel with Selective Antimicrobial Activity, Potentially Beneficial for Treatment and Prevention of Bacterial Vaginosis. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-507308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507308