Comparison of Gene Expression Profiling in Sarcomas and Mesenchymal Stem Cells Identifies Tumorigenic Pathways in Chemically Induced Rat Sarcoma Model
Joint Authors
Honoki, Kanya
Tohma, Yasuaki
Mori, Toshio
Fujii, Hiromasa
Tsukamoto, Shinji
Kido, Akira
Tanaka, Yasuhito
Tsujiuchi, Toshifumi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) are believed to be the cell of origin for most sarcomas including osteosarcoma and malignant fibrous histiocytoma (MFH/UPS).
To identify the signaling pathways involved in sarcoma pathogenesis, we compared gene expression profiles in rat osteosarcoma and MFH cells with those in syngeneic rat MSCs.
Analysis of genes that characterize MSCs such as CD44, CD105, CD73, and CD90 showed higher expression in MSCs compared to sarcomas.
Pathways involved in focal and cell adhesion, cytokine-cytokine receptors, extracellular matrix receptors, chemokines, and Wnt signaling were down-regulated in both sarcomas.
Meanwhile, DNA replication, cell cycle, mismatch repair, Hedgehog signaling, and metabolic pathways were upregulated in both sarcomas.
Downregulation of p21Cip1 and higher expression of CDK4-cyclinD1 and CDK2-cyclinE could accelerate cell cycle in sarcomas.
The current study indicated that these rat sarcomas could be a good model for their human counterparts and will provide the further insights into the molecular pathways and mechanisms involved in sarcoma pathogenesis.
American Psychological Association (APA)
Honoki, Kanya& Fujii, Hiromasa& Tohma, Yasuaki& Tsujiuchi, Toshifumi& Kido, Akira& Tsukamoto, Shinji…[et al.]. 2012. Comparison of Gene Expression Profiling in Sarcomas and Mesenchymal Stem Cells Identifies Tumorigenic Pathways in Chemically Induced Rat Sarcoma Model. ISRN Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-507318
Modern Language Association (MLA)
Honoki, Kanya…[et al.]. Comparison of Gene Expression Profiling in Sarcomas and Mesenchymal Stem Cells Identifies Tumorigenic Pathways in Chemically Induced Rat Sarcoma Model. ISRN Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-507318
American Medical Association (AMA)
Honoki, Kanya& Fujii, Hiromasa& Tohma, Yasuaki& Tsujiuchi, Toshifumi& Kido, Akira& Tsukamoto, Shinji…[et al.]. Comparison of Gene Expression Profiling in Sarcomas and Mesenchymal Stem Cells Identifies Tumorigenic Pathways in Chemically Induced Rat Sarcoma Model. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-507318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507318