Bioclinical Parameters Driving Decision-Making of Subsequent Lines of Treatment in Metastatic Castration-Resistant Prostate Cancer
Joint Authors
Ficorella, Corrado
Irelli, A.
Festuccia, Claudio
Cannita, Katia
Bruera, Gemma
Ricevuto, Enrico
Palluzzi, E.
Gravina, Giovanni Luca
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Different options are available as second-line treatment of metastatic castrate-resistant prostate cancer: cabazitaxel, abiraterone, and enzalutamide.
Phase III studies evaluating cabazitaxel and the two hormonal agents have been shown to significantly prolong overall survival compared to mitoxantrone and placebo, respectively.
Several studies have also demonstrated feasibility and activity of docetaxel rechallenge in case of a sufficient progression-free interval (3–6 months), good performance status, and previous acceptable safety profile, thus providing an additional treatment option in clinical practice.
Clinical and biological parameters should be considered to tailor II line treatment.
In clinical practice, we can primarily evaluate patients’ fitness according to age, performance status, symptomatic disease, comorbidities, and expected safety profile of each drug.
Different prognostic/predictive factors may be considered, such as presence of bone-limited or visceral metastases, length of androgen deprivation therapy (ADT) before chemotherapy, time to progression after docetaxel, Gleason score, PSA doubling time, and serum testosterone, even if their clinical relevance is still debated.
This review will discuss current options of innovative drugs sequencing and selection according to bioclinical parameters.
American Psychological Association (APA)
Irelli, A.& Bruera, Gemma& Cannita, Katia& Palluzzi, E.& Gravina, Giovanni Luca& Festuccia, Claudio…[et al.]. 2014. Bioclinical Parameters Driving Decision-Making of Subsequent Lines of Treatment in Metastatic Castration-Resistant Prostate Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-507334
Modern Language Association (MLA)
Irelli, A.…[et al.]. Bioclinical Parameters Driving Decision-Making of Subsequent Lines of Treatment in Metastatic Castration-Resistant Prostate Cancer. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-507334
American Medical Association (AMA)
Irelli, A.& Bruera, Gemma& Cannita, Katia& Palluzzi, E.& Gravina, Giovanni Luca& Festuccia, Claudio…[et al.]. Bioclinical Parameters Driving Decision-Making of Subsequent Lines of Treatment in Metastatic Castration-Resistant Prostate Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-507334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507334