A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes
Joint Authors
James, Ian E.
Deutsch, Heather A.
Pieterman, Elsbet J.
duBell, William H.
Picha, Kristen M.
Bugelski, Peter J.
Havekes, Louis M.
Ort, Tatiana A.
Makropoulos, Dorie A.
Scully, Michael S.
van den Hoek, Anita M.
Wertheimer, Joshua D.
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Patients treated with recombinant human Epo demonstrate an improvement in insulin sensitivity.
We aimed to investigate whether CNTO 530, a novel Epo receptor agonist, could affect glucose tolerance and insulin sensitivity.
A single administration of CNTO 530 significantly and dose-dependently reduced the area under the curve in a glucose tolerance test in diet-induced obese and diabetic mice after 14, 21, and 28 days.
HOMA analysis suggested an improvement in insulin sensitivity, and this effect was confirmed by a hyperinsulinemic-euglycemic clamp.
Uptake of 14C-2-deoxy-D-glucose indicated that animals dosed with CNTO 530 transported more glucose into skeletal muscle and heart relative to control animals.
In conclusion, CNTO530 has a profound effect on glucose tolerance in insulin-resistant rodents likely because of improving peripheral insulin sensitivity.
This effect was observed with epoetin-α and darbepoetin-α, suggesting this is a class effect, but the effect with these compounds relative to CNTO530 was decreased in duration and magnitude.
American Psychological Association (APA)
Scully, Michael S.& Ort, Tatiana A.& James, Ian E.& Bugelski, Peter J.& Makropoulos, Dorie A.& Deutsch, Heather A.…[et al.]. 2011. A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-507359
Modern Language Association (MLA)
Scully, Michael S.…[et al.]. A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes. Experimental Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-507359
American Medical Association (AMA)
Scully, Michael S.& Ort, Tatiana A.& James, Ian E.& Bugelski, Peter J.& Makropoulos, Dorie A.& Deutsch, Heather A.…[et al.]. A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-507359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507359