Propylthiouracil-Induced Acute Liver Failure : Role of Liver Transplantation
Joint Authors
Martin, Paul
Tzakis, Andreas G.
Garcia-Buitrago, Monica T.
Selvaggi, Gennaro
Arosemena, Leopoldo R.
Carrion, Andres F.
Tekin, Akin
Ghanta, Ravi K.
Czul, Frank
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death.
We describe two cases of acute hepatic failure due to PTU that required liver transplantation.
Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options.
Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.
American Psychological Association (APA)
Carrion, Andres F.& Czul, Frank& Arosemena, Leopoldo R.& Selvaggi, Gennaro& Garcia-Buitrago, Monica T.& Tekin, Akin…[et al.]. 2010. Propylthiouracil-Induced Acute Liver Failure : Role of Liver Transplantation. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-507419
Modern Language Association (MLA)
Carrion, Andres F.…[et al.]. Propylthiouracil-Induced Acute Liver Failure : Role of Liver Transplantation. International Journal of Endocrinology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-507419
American Medical Association (AMA)
Carrion, Andres F.& Czul, Frank& Arosemena, Leopoldo R.& Selvaggi, Gennaro& Garcia-Buitrago, Monica T.& Tekin, Akin…[et al.]. Propylthiouracil-Induced Acute Liver Failure : Role of Liver Transplantation. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-507419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507419