A Novel Mutation in Leptin Gene Is Associated with Severe Obesity in Chinese Individuals
Joint Authors
Jia, Weiping
Zhao, Yue
Hu, Cheng
Yang, Jianjun
Wu, Beibei
Liu, Xiao
Tang, Shanshan
Hong, Nanchao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Obesity is a clinical syndrome which is driven by interactions between multiple genetic and environmental factors.
Monogenic obesity is a rare type of obesity which is caused by a mutation in a single gene.
Patients with monogenic obesity may develop early onset of obesity and severe metabolic abnormalities.
In this study, we screened mutations of LEP in a total of 135 Chinese individuals including 35 obese patients whose BMI ≥32 kg/m2 and 100 controls with BMI <25 kg/m2.
Moreover, detailed information and clinical measurements of the participants were also collected.
Finally, we identified a novel nonsynonymous mutation H118L in exon 3 of LEP in one patient with BMI 46.0 kg/m2.
This mutation was not identified in the controls.
We speculated that the mutation H118L in LEP might be associated with severe obesity in Chinese subjects.
However, the substantial mechanism should be further investigated.
American Psychological Association (APA)
Zhao, Yue& Hong, Nanchao& Liu, Xiao& Wu, Beibei& Tang, Shanshan& Yang, Jianjun…[et al.]. 2014. A Novel Mutation in Leptin Gene Is Associated with Severe Obesity in Chinese Individuals. BioMed Research International،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-507460
Modern Language Association (MLA)
Zhao, Yue…[et al.]. A Novel Mutation in Leptin Gene Is Associated with Severe Obesity in Chinese Individuals. BioMed Research International No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-507460
American Medical Association (AMA)
Zhao, Yue& Hong, Nanchao& Liu, Xiao& Wu, Beibei& Tang, Shanshan& Yang, Jianjun…[et al.]. A Novel Mutation in Leptin Gene Is Associated with Severe Obesity in Chinese Individuals. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-507460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507460