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An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung : A Case Report and Review of the Literature
Joint Authors
Ribbeck, Amanda
Bartnik, John
Kumar, Ramesh
Paidipaty B, Babu
Bhamidipati, Pavan Kumar
Liaghati-Nasseri, Goldees
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Large-cell neuroendocrine carcinomas (LCNECs) are relatively rare and aggressive neoplasms of the lung with very poor prognosis.
Even though they are included in the classification of nonsmall cell carcinomas, they have a biological behaviour and physiological response to treatment more like small cell carcinomas of lung.
We report an atypical case presentation of LCNEC in a 51-year-old gentleman who presented with diffuse metastases to the thoracic and lumbar spine, brain, and liver, posing a diagnostic challenge.
The primary small central lung tumor was in close proximity to major vessels, rendering a biopsy of the primary cancer challenging and nearly impossible.
The final diagnosis was established through immunohistochemistry staining and examination of liver biopsy from a metastatic lesion.
We also included a review of the current literature pertinent to LCNEC, as well as the important role of tumor markers plus immunohistochemistry profiles in determining the origin of unknown primary tumors in such difficult patient presentations.
American Psychological Association (APA)
Bhamidipati, Pavan Kumar& Ribbeck, Amanda& Liaghati-Nasseri, Goldees& Kumar, Ramesh& Paidipaty B, Babu& Bartnik, John. 2011. An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung : A Case Report and Review of the Literature. Lung Cancer International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-507465
Modern Language Association (MLA)
Bhamidipati, Pavan Kumar…[et al.]. An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung : A Case Report and Review of the Literature. Lung Cancer International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-507465
American Medical Association (AMA)
Bhamidipati, Pavan Kumar& Ribbeck, Amanda& Liaghati-Nasseri, Goldees& Kumar, Ramesh& Paidipaty B, Babu& Bartnik, John. An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung : A Case Report and Review of the Literature. Lung Cancer International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-507465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507465