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Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection
Joint Authors
Ždralević, Maša
Marra, Ersilia
Antonacci, Lucia
Guaragnella, Nicoletta
Giannattasio, Sergio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Cell homeostasis results from the balance between cell capability to adapt or succumb to environmental stress.
Mitochondria, in addition to supplying cellular energy, are involved in a range of processes deciding about cellular life or death.
The crucial role of mitochondria in cell death is well recognized.
Mitochondrial dysfunction has been associated with the death process and the onset of numerous diseases.
Yet, mitochondrial involvement in cellular adaptation to stress is still largely unexplored.
Strong interest exists in pharmacological manipulation of mitochondrial metabolism and signaling.
The yeast Saccharomyces cerevisiae has proven a valuable model organism in which several intracellular processes have been characterized in great detail, including the retrograde response to mitochondrial dysfunction and, more recently, programmed cell death.
In this paper we review experimental evidences of mitochondrial involvement in cytoprotection and propose yeast as a model system to investigate the role of mitochondria in the cross-talk between prosurvival and prodeath pathways.
American Psychological Association (APA)
Ždralević, Maša& Guaragnella, Nicoletta& Antonacci, Lucia& Marra, Ersilia& Giannattasio, Sergio. 2012. Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-507468
Modern Language Association (MLA)
Ždralević, Maša…[et al.]. Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-507468
American Medical Association (AMA)
Ždralević, Maša& Guaragnella, Nicoletta& Antonacci, Lucia& Marra, Ersilia& Giannattasio, Sergio. Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-507468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507468