Understanding Nephrogenic Systemic Fibrosis
Joint Authors
Shah, Silvi
Chopra, Tushar
Kandukurti, Kiran
Ahmed, Raheel
Panesar, Mandip
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Nephrogenic systemic fibrosis (NSF) is a rare and a debilitating disease noted uncommonly in patients with impaired renal function when exposed to low-stability gadolinium-based contrast agents (Gd-CAs).
According to experimental studies, cytokines released by the stimulation of effector cells such as skin macrophages and peripheral blood monocytes activate circulating fibroblasts which play a major role in the development of NSF lesions.
The presence of permissive factors, presumably, provides an environment conducive to facilitate the process of fibrosis.
Multiple treatment modalities have been tried with variable success rates.
More research is necessary to elucidate the underlying pathophysiological mechanisms which could potentially target the initial steps of fibrosis in these patients.
This paper attempts to collate the inferences from the in vivo and in vitro experiments to the clinical observations to understand the pathogenesis of NSF.
Schematic representations of receptor-mediated molecular pathways of activation of macrophages and fibroblasts by gadolinium and the final pathway to fibrosis are incorporated in the discussion.
American Psychological Association (APA)
Chopra, Tushar& Kandukurti, Kiran& Shah, Silvi& Ahmed, Raheel& Panesar, Mandip. 2012. Understanding Nephrogenic Systemic Fibrosis. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-507472
Modern Language Association (MLA)
Chopra, Tushar…[et al.]. Understanding Nephrogenic Systemic Fibrosis. International Journal of Nephrology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-507472
American Medical Association (AMA)
Chopra, Tushar& Kandukurti, Kiran& Shah, Silvi& Ahmed, Raheel& Panesar, Mandip. Understanding Nephrogenic Systemic Fibrosis. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-507472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507472