Vascular and Neural Dysfunctions in Obese Zucker Rats : Effect of AVE7688
Joint Authors
Yorek, Mark A.
Kleinschmidt, Travis L.
Davidson, Eric P.
Oltman, Christine L.
Coppey, Lawrence J.
Source
Experimental Diabetes Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to determine whether AVE7688 a drug that inhibits both angiotensin converting enzyme and neutral endopeptidase activity protects vascular and nerve functions in an animal model of metabolic syndrome.
Obese Zucker rats at 20 weeks of age were treated for 12 weeks with AVE7688.
Vasodilation in epineurial arterioles was measured by videomicroscopy and nerve conduction velocity was measured following electrical stimulation.
Treatment with AVE7688 improved vascular relaxation in response to acetylcholine and motor and sensory nerve conduction velocity.
In obese Zucker rats superoxide levels and nitrotyrosine staining were elevated in the aorta and treatment corrected both conditions.
Obese Zucker rats were hypoalgesic in response to a thermal stimulus and demonstrated signs of impaired tactile response and both conditions were significantly improved with treatment.
Even though obese Zucker rats are normoglycemic vascular and neural dysfunctions develop with age and can be improved by treatment with AVE7688.
American Psychological Association (APA)
Davidson, Eric P.& Coppey, Lawrence J.& Kleinschmidt, Travis L.& Oltman, Christine L.& Yorek, Mark A.. 2009. Vascular and Neural Dysfunctions in Obese Zucker Rats : Effect of AVE7688. Experimental Diabetes Research،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-507477
Modern Language Association (MLA)
Davidson, Eric P.…[et al.]. Vascular and Neural Dysfunctions in Obese Zucker Rats : Effect of AVE7688. Experimental Diabetes Research No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-507477
American Medical Association (AMA)
Davidson, Eric P.& Coppey, Lawrence J.& Kleinschmidt, Travis L.& Oltman, Christine L.& Yorek, Mark A.. Vascular and Neural Dysfunctions in Obese Zucker Rats : Effect of AVE7688. Experimental Diabetes Research. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-507477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507477