Enhancing Diagnostic Accuracy of aMCI in the Elderly : Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype
Joint Authors
Asmarinah,
Machfoed, Moh. Hasan
Waspadji, Sarwono
Amir, Nurmiati
Handayani, Yvonne Suzy
Turana, Yuda
Purba, Jan Sudir
Ranakusuma, Teguh Asaat S.
Ahmad, Siti Airiza
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Amnestic Mild Cognitive Impairment (aMCI) often progresses to Alzheimer’s disease.
There are clinical markers and biomarkers to identify the degenerative process in the brain.
Objectives.
To obtain the diagnostic values of olfactory test, pupillary response to tropicamide 0.01%, BDNF plasma level, and APOE ε4 in diagnosing aMCI.
Methods.
Cross-sectional, comparative analysis.
Results.
There were 109 subjects enrolled (aMCI: 51, normal cognition: 58) with age 64 ± 5.54 years.
For diagnosing aMCI, cut-off point for the olfactory score was <7 out of 10 and >22% for pupil dilatation response.
Low BDNF plasma level was related significantly with olfactory deficits and aMCI (P<0.05).
Four of five subjects with homozygote e4 presented with multiple-domain aMCI.
This group displayed the lowest means of olfactory score and the highest means of pupillary hypersensitivity response (P<0.0001).
Combination of olfactory deficit and pupillary hypersensitivity response in detection of aMCI was beneficial with Sp 91% and PPV 87%.
In conjunction with clinical markers, BDNF plasma level and presence of APOE e4+ improved Sp and PPV.
Conclusions.
Combination of olfactory test and pupillary response test was useful as diagnostic tool in aMCI.
In conjunction with clinical markers, low level of BDNF plasma and presence of APOE e4 improved the diagnostic value.
American Psychological Association (APA)
Turana, Yuda& Ranakusuma, Teguh Asaat S.& Purba, Jan Sudir& Amir, Nurmiati& Ahmad, Siti Airiza& Machfoed, Moh. Hasan…[et al.]. 2014. Enhancing Diagnostic Accuracy of aMCI in the Elderly : Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype. International Journal of Alzheimer's Disease،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-507505
Modern Language Association (MLA)
Turana, Yuda…[et al.]. Enhancing Diagnostic Accuracy of aMCI in the Elderly : Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype. International Journal of Alzheimer's Disease No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-507505
American Medical Association (AMA)
Turana, Yuda& Ranakusuma, Teguh Asaat S.& Purba, Jan Sudir& Amir, Nurmiati& Ahmad, Siti Airiza& Machfoed, Moh. Hasan…[et al.]. Enhancing Diagnostic Accuracy of aMCI in the Elderly : Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype. International Journal of Alzheimer's Disease. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-507505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507505