Genetics of Behçet's Disease
Author
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Behçet's disease (BD) is a systemic inflammatory disorder characterized mainly by recurrent oral and genital ulcers and eye involvement.
Although the pathogenesis remains poorly understood, a variety of studies have demonstrated that genetic predisposition is a major factor in disease susceptibility.
Peculiar geographical distribution of BD along the ancient Silk Road has been regarded as evidence supporting genetic influence.
The observed aggregation of BD in families of patients with BD is also supportive for a genetic component in its etiology.
HLA-B51 (B510101 subtype) is the most strongly associated genetic marker for BD in countries on the Silk Road.
In recent years, several genome-wide association studies and genetic polymorphism studies have also found new genetic associations with BD, which may have a supplementary role in disease susceptibility and/or severity.
The author reviewed the HLA and non-HLA genetic association studies.
American Psychological Association (APA)
Kaya, Tamer İrfan. 2011. Genetics of Behçet's Disease. Pathology Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507507
Modern Language Association (MLA)
Kaya, Tamer İrfan. Genetics of Behçet's Disease. Pathology Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-507507
American Medical Association (AMA)
Kaya, Tamer İrfan. Genetics of Behçet's Disease. Pathology Research International. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507507