Fundamental Dynamical Modes Underlying Human Brain Synchronization

Abstract EN

Little is known about the long-term dynamics of widely interacting cortical and subcortical networks during the wake-sleep cycle.

Using large-scale intracranial recordings of epileptic patients during seizure-free periods, we investigated local- and long-range synchronization between multiple brain regions over several days.

For such high-dimensional data, summary information is required for understanding and modelling the underlying dynamics.

Here, we suggest that a compact yet useful representation is given by a state space based on the first principal components.

Using this representation, we report, with a remarkable similarity across the patients with different locations of electrode placement, that the seemingly complex patterns of brain synchrony during the wake-sleep cycle can be represented by a small number of characteristic dynamic modes.

In this space, transitions between behavioral states occur through specific trajectories from one mode to another.

These findings suggest that, at a coarse level of temporal resolution, the different brain states are correlated with several dominant synchrony patterns which are successively activated across wake-sleep states.