HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia
Joint Authors
García-Suastegui, Wendy Argelia
Peralta-Zaragoza, Oscar
Gómez-Cerón, Claudia
Deas, Jessica
Jacobo-Herrera, Nadia Judith
Fierros-Zárate, Geny del Socorro
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention.
Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer.
HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia, and in treatment strategies for invasive cervical cancer.
It is known that during the development of cervical cancer associated with HPV infection, a cascade of abnormal events is induced, including disruption of cellular cycle control, alteration of gene expression, and deregulation of microRNA expression.
Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells.
Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer.
American Psychological Association (APA)
Peralta-Zaragoza, Oscar& Deas, Jessica& Gómez-Cerón, Claudia& García-Suastegui, Wendy Argelia& Fierros-Zárate, Geny del Socorro& Jacobo-Herrera, Nadia Judith. 2013. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-507533
Modern Language Association (MLA)
Peralta-Zaragoza, Oscar…[et al.]. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia. Obstetrics and Gynecology International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-507533
American Medical Association (AMA)
Peralta-Zaragoza, Oscar& Deas, Jessica& Gómez-Cerón, Claudia& García-Suastegui, Wendy Argelia& Fierros-Zárate, Geny del Socorro& Jacobo-Herrera, Nadia Judith. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-507533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507533