![](/images/graphics-bg.png)
Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats
Joint Authors
Kamanyi, A.
Mbiantcha, M.
Watcho, Pierre
Teponno, R. B.
Nguelefack, Télesphore Benoît
Tapondjou, A. L.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L.
var sativa (Dioscoreaceae)—evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%.
The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin.
The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities.
These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins.
Thus, the analgesic activity of the bulbils of Dioscorea bulbifera may be at least partially linked to its anti-inflammatory activity.
American Psychological Association (APA)
Mbiantcha, M.& Kamanyi, A.& Teponno, R. B.& Tapondjou, A. L.& Watcho, Pierre& Nguelefack, Télesphore Benoît. 2010. Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507553
Modern Language Association (MLA)
Nguelefack, Télesphore Benoît…[et al.]. Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-507553
American Medical Association (AMA)
Mbiantcha, M.& Kamanyi, A.& Teponno, R. B.& Tapondjou, A. L.& Watcho, Pierre& Nguelefack, Télesphore Benoît. Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507553