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Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Calorie restriction (CR) is an intervention extending the life spans of many organisms.
The mechanisms underlying CR-dependent retardation of aging are still poorly understood.
Despite mechanisms involving conserved nutrient signaling pathways proposed, few target processes that can account for CR-mediated longevity have so far been identified.
Recently, both peroxiredoxins and vacuolar-ATPases were reported to control CR-mediated retardation of aging downstream of conserved nutrient signaling pathways.
In this review, we focus on peroxiredoxin-mediated stress-defence and vacuolar-ATPase regulated acidification and pinpoint common denominators between the two mechanisms proposed for how CR extends life span.
Both the activities of peroxiredoxins and vacuolar-ATPases are stimulated upon CR through reduced activities in conserved nutrient signaling pathways and both seem to stimulate cellular resistance to peroxide-stress.
However, whereas vacuolar-ATPases have recently been suggested to control both Ras-cAMP-PKA- and TORC1-mediated nutrient signaling, neither the physiological benefits of a proposed role for peroxiredoxins in H2O2-signaling nor downstream targets regulated are known.
Both peroxiredoxins and vacuolar-ATPases do, however, impinge on mitochondrial iron-metabolism and further characterization of their impact on iron homeostasis and peroxide-resistance might therefore increase our understanding of the beneficial effects of CR on aging and age-related diseases.
American Psychological Association (APA)
Molin, Mikael& Demir, Ayse Banu. 2014. Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-507563
Modern Language Association (MLA)
Molin, Mikael& Demir, Ayse Banu. Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension. International Journal of Cell Biology No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-507563
American Medical Association (AMA)
Molin, Mikael& Demir, Ayse Banu. Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-507563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507563