CD34 Expression in the Stromal Cells of Alveolar Adenoma
Joint Authors
Maiorino, Alfonso
Sellitto, Carmine
De Rosa, Ilaria
Amore, Dario
De Rosa, Nicolina
Curcio, Carlo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The alveolar adenoma of the lung is a rare benign tumor characterized by a proliferation of both the alveolar epithelial cells and the mesenchymal septal cells.
Immunohistochemically, the epithelial cells stain for cytokeratin (CK) AE1AE3, CK7, thyroid transcription factor 1 (TTF1), and surfactant apoprotein confirming the derivation by the type 2 pneumocytes.
The stromal cells are negative for these markers but they show focally smooth muscle and muscle-specific actin positivity.
We describe two cases that showed immunohistochemically a CD34 positivity of the mesenchymal septal cells.
This aspect has been previously described in a two cases report, but not emphasized by the authors as a distinctive feature of the lesion.
We consider this CD34 positivity as a marker of immaturity or stemness of the lesional septal spindle cells, that could be responsible of the different phenotypic and morphological profile of the interstitial cells, that could be, therefore, considered neoplastic and not reactive.
American Psychological Association (APA)
De Rosa, Nicolina& Maiorino, Alfonso& De Rosa, Ilaria& Curcio, Carlo& Sellitto, Carmine& Amore, Dario. 2012. CD34 Expression in the Stromal Cells of Alveolar Adenoma. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-507595
Modern Language Association (MLA)
De Rosa, Nicolina…[et al.]. CD34 Expression in the Stromal Cells of Alveolar Adenoma. Case Reports in Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-507595
American Medical Association (AMA)
De Rosa, Nicolina& Maiorino, Alfonso& De Rosa, Ilaria& Curcio, Carlo& Sellitto, Carmine& Amore, Dario. CD34 Expression in the Stromal Cells of Alveolar Adenoma. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-507595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507595