Platelet-Activating Factor Induces Th17 Cell Differentiation
Joint Authors
Stankovà, Jana
Thivierge, Maryse
Drolet, Anne-Marie
Rola-Pleszczynski, Marek
Hanna, Dominique
Maynard, Bruno
Turcotte, Sylvie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Th17 cells have been implicated in a number of inflammatory and autoimmune diseases.
The phospholipid mediator platelet-activating factor (PAF) is found in increased concentrations in inflammatory lesions and has been shown to induce IL-6 production.
We investigated whether PAF could affect the development of Th17 cells.
Picomolar concentrations of PAF induced IL-23, IL-6, and IL-1β expression in monocyte-derived Langerhans cells (LCs) and in keratinocytes.
Moreover, when LC were pretreated with PAF and then cocultured with anti-CD3- and anti-CD28-activated T cells, the latter developed a Th17 phenotype, with a significant increase in the expression of the transcriptional regulator RORγt and enhanced expression of IL-17, IL-21, and IL-22.
PAF-induced Th17 development was prevented by the PAF receptor antagonist WEB2086 and by neutralizing antibodies to IL-23 and IL-6R.
This may constitute a previously unknown stimulus for the development and persistence of inflammatory processes that could be amenable to pharmacologic intervention.
American Psychological Association (APA)
Drolet, Anne-Marie& Thivierge, Maryse& Turcotte, Sylvie& Hanna, Dominique& Maynard, Bruno& Stankovà, Jana…[et al.]. 2011. Platelet-Activating Factor Induces Th17 Cell Differentiation. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-507620
Modern Language Association (MLA)
Drolet, Anne-Marie…[et al.]. Platelet-Activating Factor Induces Th17 Cell Differentiation. Mediators of Inflammation No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-507620
American Medical Association (AMA)
Drolet, Anne-Marie& Thivierge, Maryse& Turcotte, Sylvie& Hanna, Dominique& Maynard, Bruno& Stankovà, Jana…[et al.]. Platelet-Activating Factor Induces Th17 Cell Differentiation. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-507620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507620