Morphological Factor Estimation via High-Dimensional Reduction : Prediction of MCI Conversion to Probable AD
Joint Authors
Mouiha, Abderazzak
Duchesne, Simon
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We propose a novel morphological factor estimate from structural MRI for disease state evaluation.
We tested this methodology in the context of Alzheimer's disease (AD) with 349 subjects.
The method consisted in (a) creating a reference MRI feature eigenspace using intensity and local volume change data from 149 healthy, young subjects; (b) projecting MRI data from 75 probable AD, 76 controls (CTRL), and 49 Mild Cognitive Impairment (MCI) in that space; (c) extracting high-dimensional discriminant functions; (d) calculating a single morphological factor based on various models.
We used this methodology in leave-one-out experiments to (1) confirm the superiority of an inverse-squared model over other approaches; (2) obtain accuracy estimates for the discrimination of probable AD from CTRL (90%) and the prediction of conversion of MCI subjects to probable AD (79.4%).
American Psychological Association (APA)
Duchesne, Simon& Mouiha, Abderazzak. 2011. Morphological Factor Estimation via High-Dimensional Reduction : Prediction of MCI Conversion to Probable AD. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507642
Modern Language Association (MLA)
Duchesne, Simon& Mouiha, Abderazzak. Morphological Factor Estimation via High-Dimensional Reduction : Prediction of MCI Conversion to Probable AD. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-507642
American Medical Association (AMA)
Duchesne, Simon& Mouiha, Abderazzak. Morphological Factor Estimation via High-Dimensional Reduction : Prediction of MCI Conversion to Probable AD. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507642