Dietary Polyphenols as Modulators of Brain Functions : Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Accumulating evidence suggests that diet and lifestyle can play an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function.
In particular, polyphenols have been reported to exert their neuroprotective actions through the potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning, and cognitive function.
Despite significant advances in our understanding of the biology of polyphenols, they are still mistakenly regarded as simply acting as antioxidants.
However, recent evidence suggests that their beneficial effects involve decreases in oxidative/inflammatory stress signaling, increases in protective signaling and neurohormetic effects leading to the expression of genes that encode antioxidant enzymes, phase-2 enzymes, neurotrophic factors, and cytoprotective proteins.
Specific examples of such pathways include the sirtuin-FoxO pathway, the NF-κB pathway, and the Nrf-2/ARE pathway.
Together, these processes act to maintain brain homeostasis and play important roles in neuronal stress adaptation and thus polyphenols have the potential to prevent the progression of neurodegenerative pathologies.
American Psychological Association (APA)
Vauzour, David. 2012. Dietary Polyphenols as Modulators of Brain Functions : Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-507667
Modern Language Association (MLA)
Vauzour, David. Dietary Polyphenols as Modulators of Brain Functions : Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-507667
American Medical Association (AMA)
Vauzour, David. Dietary Polyphenols as Modulators of Brain Functions : Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-507667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507667