Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
Reflux of duodenal contents can induce mucosal injury, stimulate cell proliferation, and promote tumorigenesis.
We examined the expression of COX2 and p53 in rat esophageal lesions induced by duodenal content reflux.
Methods.
Thirty 8-week-old male Wistar rats were exposed to duodenal content esophageal reflux.
All animals underwent an esophagoduodenal anastomosis (EDA) with total gastrectomy in order to produce chronic esophagitis.
Ten rats were the sham.
Control.
They were sacrificed at the 40th week.
Their esophagi were examined for HE, COX2, p53, and proliferating cell nuclear antigen (PCNA).
Results.
After 40 weeks of reflux, dysplasia, squamous cell carcinoma (SCC), and adenocarcinoma (ADC) were found.
PCNA labeling index was higher in dysplastic and cancer tissue than that in normal.
Overexpression of COX2 was shown in ADC and SCC.
Wild-type p53 accumulation was found in ADC, and not in SCC.
Conclusion.
Reflux of duodenal contents into the esophagus led to ADC and SCC in rats.
COX2 may play an important role in esophageal cancer by duodenal content reflux.
Our present results suggest an association between wild-type p53 accumulation and COX2 expression in ADC, with no such relation seen in SCC.
American Psychological Association (APA)
Hashimoto, Naoki. 2012. Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-507708
Modern Language Association (MLA)
Hashimoto, Naoki. Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents. ISRN Gastroenterology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-507708
American Medical Association (AMA)
Hashimoto, Naoki. Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-507708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507708