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Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level Aluminum Ingestion in a Translational Rat Model Provides an Explanation of Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
A translational aging rat model for chronic aluminum (Al) neurotoxicity mimics human Al exposure by ingesting Al, throughout middle age and old age, in equivalent amounts to those ingested by Americans from their food, water, and Al additives.
Most rats that consumed Al in an amount equivalent to the high end of the human total dietary Al range developed severe cognitive deterioration in old age.
High-stage Al accumulation occurred in the entorhinal cortical cells of origin for the perforant pathway and hippocampal CA1 cells, resulting in microtubule depletion and dendritic dieback.
Analogous pathological change in humans leads to destruction of the perforant pathway and Alzheimer's disease dementia.
The hippocampus is thereby isolated from neocortical input and output normally mediated by the entorhinal cortex.
Additional evidence is presented that Al is involved in the formation of neurofibrillary tangles, amyloid plaques, granulovacuolar degeneration, and other pathological changes of Alzheimer’s disease (AD).
The shared characteristics indicate that AD is a human form of chronic Al neurotoxicity.
This translational animal model provides fresh strategies for the prevention, diagnosis, and treatment of AD.
American Psychological Association (APA)
Walton, J. R.. 2012. Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level Aluminum Ingestion in a Translational Rat Model Provides an Explanation of Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-507716
Modern Language Association (MLA)
Walton, J. R.. Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level Aluminum Ingestion in a Translational Rat Model Provides an Explanation of Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-507716
American Medical Association (AMA)
Walton, J. R.. Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level Aluminum Ingestion in a Translational Rat Model Provides an Explanation of Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-507716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507716