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Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression
Joint Authors
Liu, Hongsheng
Wu, Xiaoping
Ma, Mingyue
Zhang, Hongbo
Li, Shengbin
Gao, Yanjun
Yang, Rui
Yang, Junle
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sertraline, one of the oldest antidepressants, remains to be the most efficacious treatment for depression.
However, major depression disorder (MDD) is characterized by altered emotion processing and deficits in cognitive control.
In cognitive interference tasks, patients with MDD have shown excessive hypothalamus activity.
The purpose of this study was to examine the effects of antidepressant treatment (sertraline) on hypothalamus-anchored resting brain circuitry.
Functional magnetic resonance imaging was conducted on depressed patients (n=12) both before and after antidepressant treatment.
After eight weeks of antidepressant treatment, patients with depression showed significantly increased connectivity between the hypothalamus and dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, insula, putamen, caudate, and claustrum.
By contrast, decreased connectivity of the hypothalamus-related areas was primarily located in the inferior frontal gyrus, medial frontal gyrus, cingulated gyrus, precuneus, thalamus, and cerebellum.
After eight weeks of antidepressant therapy, 8 out of the 12 depressed subjects achieved 70% reduction or better in depressive symptoms, as measured on the Hamilton depression rating scale.
Our findings may infer that antidepressant treatment can alter the functional connectivity of the hypothalamus resting brain to achieve its therapeutic effect.
American Psychological Association (APA)
Yang, Rui& Zhang, Hongbo& Wu, Xiaoping& Yang, Junle& Ma, Mingyue& Gao, Yanjun…[et al.]. 2014. Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-507721
Modern Language Association (MLA)
Yang, Rui…[et al.]. Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-507721
American Medical Association (AMA)
Yang, Rui& Zhang, Hongbo& Wu, Xiaoping& Yang, Junle& Ma, Mingyue& Gao, Yanjun…[et al.]. Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-507721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507721