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Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly
Joint Authors
Mader, Scott L.
Schutzer, William E.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypertension, orthostatic hypotension, arterial insufficiency, and atherosclerosis are common disorders in the elderly that lead to significant morbidity and mortality.
One common factor to these conditions is an age-related decline in vascular beta-adrenergic receptor-mediated function and subsequent cAMP generation.
Presently, there is no single cellular factor that can explain this age-related decline, and thus, the primary cause of this homeostatic imbalance is yet to be identified.
However, the etiology is clearly associated with an age-related change in the ability of beta-adrenergic receptor to respond to agonist at the cellular level in the vasculature.
This paper will review what is presently understood regarding the molecular and biochemical basis of age-impaired beta-adrenergic receptor-mediated signaling.
A fundamental understanding of why β-AR-mediated vasorelaxation is impaired with age will provide new insights and innovative strategies for the management of multiple clinical disorders.
American Psychological Association (APA)
Schutzer, William E.& Mader, Scott L.. 2011. Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-507726
Modern Language Association (MLA)
Schutzer, William E.& Mader, Scott L.. Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly. International Journal of Hypertension No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-507726
American Medical Association (AMA)
Schutzer, William E.& Mader, Scott L.. Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-507726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507726