Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction
Joint Authors
Apte, Kishori
Puranik, Amrutesh S.
Halade, Ganesh
Mogre, Ranjan
Patwardhan, Bhushan
Kumar, Sandeep
Vaidya, Ashok D. B.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Safety pharmacology studies help in identifying preclinical adverse drug reactions.
We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks.
Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses.
The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin.
Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.
American Psychological Association (APA)
Puranik, Amrutesh S.& Halade, Ganesh& Kumar, Sandeep& Mogre, Ranjan& Apte, Kishori& Vaidya, Ashok D. B.…[et al.]. 2011. Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507750
Modern Language Association (MLA)
Puranik, Amrutesh S.…[et al.]. Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-507750
American Medical Association (AMA)
Puranik, Amrutesh S.& Halade, Ganesh& Kumar, Sandeep& Mogre, Ranjan& Apte, Kishori& Vaidya, Ashok D. B.…[et al.]. Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507750