Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin
Joint Authors
Furuyama, Akira
Jin, You-Hong
Takemura, Motohide
Yonehara, Norifumi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Transient receptor potential vanilloid1 (TRPV1) and glutamate receptors (GluRs) are located in small diameter primary afferent neurons (nociceptors), and it was speculated that glutamate released in the peripheral tissue in response to activation of TRPV1 might activate nociceptors retrogradely.
But, it was not clear which types of GluRs are functioning in the nociceptive sensory transmission.
In the present study, we examined the c-Fos expression in spinal cord dorsal horn following injection of drugs associated with glutamate receptors with/without capsaicin into the hindpaw.
The subcutaneous injection of capsaicin or glutamate remarkably evoked c-Fos expression in ipsilateral sides of spinal cord dorsal horn.
This capsaicin evoked increase of c-Fos expression was significantly prevented by concomitant administration of MK801, CNQX, and CPCCOEt.
On the other hand, there were not any significant changes in coinjection of capsaicin and MCCG or MSOP.
These results reveal that the activation of iGluRs and group I mGluR in peripheral afferent nerves play an important role in mechanisms whereby capsaicin evokes/maintains nociceptive responses.
American Psychological Association (APA)
Jin, You-Hong& Takemura, Motohide& Furuyama, Akira& Yonehara, Norifumi. 2011. Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-507793
Modern Language Association (MLA)
Jin, You-Hong…[et al.]. Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin. Pain Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-507793
American Medical Association (AMA)
Jin, You-Hong& Takemura, Motohide& Furuyama, Akira& Yonehara, Norifumi. Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin. Pain Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-507793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507793