In Vitro Larvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles
Joint Authors
Rajakumar, Govindasamy
Bharathi, A.
Roopan, Selvaraj Mohana
Rahuman, Abdul Abdul
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Many naturally occurring and synthetic compounds containing dihydrocyanopyridine and cyanopyran moiety show pharmacological properties.
The aim of this study is to investigate the larvicidal and antioxidant potential of dihydrophenanthroline-3-carbonitrile derivatives 4a–f.
A novel series of 2-amino-10-chloro-4,12-diphenyl-1,4,5,6-tetrahydrobenzo[j][1,7]phenanthroline-3-carbonitrile derivatives were synthesized by reacting different substituted acridine chalcones through Michel addition.
The compounds were synthesized in excellent yields and the structures were corroborated on the basis of FT-IR, 1H NMR, 13C NMR, and ESI Mass analysis data.
All the synthesized compounds were evaluated for larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae.
Furthermore, the antioxidant activity was studied by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method.
From the antioxidant assay, the compound 4c was reported with profound antioxidant potential.
American Psychological Association (APA)
Bharathi, A.& Roopan, Selvaraj Mohana& Rahuman, Abdul Abdul& Rajakumar, Govindasamy. 2014. In Vitro Larvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-507799
Modern Language Association (MLA)
Bharathi, A.…[et al.]. In Vitro Larvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-507799
American Medical Association (AMA)
Bharathi, A.& Roopan, Selvaraj Mohana& Rahuman, Abdul Abdul& Rajakumar, Govindasamy. In Vitro Larvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-507799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507799