Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−− Mice
Joint Authors
Hart, Joanne L.
Ford, Asha
al-Magableh, Mohammad
Gaspari, Tracey A.
Source
International Journal of Vascular Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hydrogen sulfide is emerging as an important mediator of vascular function that has antioxidant and cytoprotective effects.
The aim of this study was to investigate the role of endogenous H2S and the effect of chronic exogenous H2S treatment on vascular function during the progression of atherosclerotic disease.
ApoE−/− mice were fed a high-fat diet for 16 weeks and treated with the H2S donor NaHS or the cystathionine-γ-lyase (CSE) inhibitor D,L-propargylglycine (PPG), to inhibit endogenous H2S production for the final 4 weeks.
Fat-fed ApoE−/− mice displayed significant aortic atherosclerotic lesions and significantly impaired endothelial function compared to wild-type mice.
Importantly, 4 weeks of NaHS treatment significantly reduced vascular dysfunction and inhibited vascular superoxide generation.
NaHS treatment significantly reduced the area of aortic atherosclerotic lesions and attenuated systolic blood pressure.
Interestingly, inhibiting endogenous, CSE-dependent H2S production with PPG did not exacerbate the deleterious vascular changes seen in the untreated fat-fed ApoE−/− mice.
The results indicate NaHS can improve vascular function by reducing vascular superoxide generation and impairing atherosclerotic lesion development.
Endogenous H2S production via CSE is insufficient to counter the atherogenic effects seen in this model; however exogenous H2S treatment has a significant vasoprotective effect.
American Psychological Association (APA)
Ford, Asha& al-Magableh, Mohammad& Gaspari, Tracey A.& Hart, Joanne L.. 2013. Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−− Mice. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-507819
Modern Language Association (MLA)
Ford, Asha…[et al.]. Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−− Mice. International Journal of Vascular Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-507819
American Medical Association (AMA)
Ford, Asha& al-Magableh, Mohammad& Gaspari, Tracey A.& Hart, Joanne L.. Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−− Mice. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-507819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507819