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Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA and folP
Joint Authors
Rwenyonyi, Charles Mugisha
Kironde, Fred
William, Buwembo
Swedberg, Göte
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
The selection of antibiotic resistance by cotrimoxazole prophylaxis was evaluated, and we characterized the mechanism of cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus.
In vitro susceptibility to six antibiotics was evaluated on 64 mutans streptococci group (MSG) isolates from a cotrimoxazole prophylaxis group and compared to 84 MSG isolates from a nonprophylaxis group.
The folA and folP genes were sequenced and compared with reference sequences at NCBI.
Only resistance to cotrimoxazole was significantly higher in the prophylaxis group (54.7% versus 15.5%, OR=6.59, 95% CI: 2.89–15.3, P<0.05).
Resistance to amoxicillin, ceftriaxone, chloramphenicol, erythromycin, and tetracycline was 1.4%, 25.5%, 6.2%, 6.5%, and 29.6% of the isolates, respectively.
Considerable polymorphisms were found in the folP gene in S.
mutans, but this could not be linked to sulfonamide drug resistance.
No variation was seen in folP or folA genes of S.
sobrinus.
Genetic transfer of folate pathway genes seems unlikely in these isolates.
American Psychological Association (APA)
William, Buwembo& Rwenyonyi, Charles Mugisha& Swedberg, Göte& Kironde, Fred. 2012. Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA and folP. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-507823
Modern Language Association (MLA)
William, Buwembo…[et al.]. Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA and folP. International Journal of Microbiology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-507823
American Medical Association (AMA)
William, Buwembo& Rwenyonyi, Charles Mugisha& Swedberg, Göte& Kironde, Fred. Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA and folP. International Journal of Microbiology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-507823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507823