![](/images/graphics-bg.png)
Power of Proteomics in Linking Oxidative Stress and Female Infertility
Joint Authors
Sharma, Rakesh
Agarwal, Ashok
Gupta, Sajal
Halabi, Jacques
Ghulmiyyah, Jana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide.
Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways in differential expression of proteins and in these diseases.
The emerging field of proteomics has allowed identification of proteins involved in cell cycle, as antioxidants, extracellular matrix (ECM), cytoskeleton, and their linkage to oxidative stress in female infertility related diseases.
The aim of this paper is to assess the association of oxidative stress and protein expression in the reproductive microenvironments such as endometrial fluid, peritoneal fluid, and follicular fluid, as well as reproductive tissues and serum.
The review also highlights the literature that proposes the use of the fertility related proteins as potential biomarkers for noninvasive and early diagnosis of the aforementioned diseases rather than utilizing the more invasive methods used currently.
The review will highlight the power of proteomic profiles identified in infertility related disease conditions and their linkage with underlying oxidative stress.
The power of proteomics will be reviewed with regard to eliciting molecular mechanisms for early detection and management of these infertility related conditions.
American Psychological Association (APA)
Gupta, Sajal& Ghulmiyyah, Jana& Sharma, Rakesh& Halabi, Jacques& Agarwal, Ashok. 2014. Power of Proteomics in Linking Oxidative Stress and Female Infertility. BioMed Research International،Vol. 2014, no. 2014, pp.1-26.
https://search.emarefa.net/detail/BIM-507830
Modern Language Association (MLA)
Gupta, Sajal…[et al.]. Power of Proteomics in Linking Oxidative Stress and Female Infertility. BioMed Research International No. 2014 (2014), pp.1-26.
https://search.emarefa.net/detail/BIM-507830
American Medical Association (AMA)
Gupta, Sajal& Ghulmiyyah, Jana& Sharma, Rakesh& Halabi, Jacques& Agarwal, Ashok. Power of Proteomics in Linking Oxidative Stress and Female Infertility. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-26.
https://search.emarefa.net/detail/BIM-507830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507830