Oxidative Stress and Vascular Damage in Hypertension : Role of Angiotensin II
Joint Authors
Duranti, Emiliano
Taddei, Stefano
Virdis, Agostino
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Reactive oxygen species are oxygen derivates and play an active role in vascular biology.
These compounds are generated within the vascular wall, at the level of endothelial and vascular smooth muscle cells, as well as by adventitial fibroblasts.
In healthy conditions, ROS are produced in a controlled manner at low concentrations and function as signaling molecules regulating vascular contraction-relaxation and cell growth.
Physiologically, the rate of ROS generation is counterbalanced by the rate of elimination.
In hypertension, an enhanced ROS generation occurs, which is not counterbalanced by the endogenous antioxidant mechanisms, leading to a state of oxidative stress.
In the present paper, major angiotensin II-induced vascular ROS generation within the vasculature, and relative sources, will be discussed.
Recent development of signalling pathways whereby angiotensin II-driven vascular ROS induce and accelerate functional and structural vascular injury will be also considered.
American Psychological Association (APA)
Virdis, Agostino& Duranti, Emiliano& Taddei, Stefano. 2011. Oxidative Stress and Vascular Damage in Hypertension : Role of Angiotensin II. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-507839
Modern Language Association (MLA)
Virdis, Agostino…[et al.]. Oxidative Stress and Vascular Damage in Hypertension : Role of Angiotensin II. International Journal of Hypertension No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-507839
American Medical Association (AMA)
Virdis, Agostino& Duranti, Emiliano& Taddei, Stefano. Oxidative Stress and Vascular Damage in Hypertension : Role of Angiotensin II. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-507839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507839