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Nucleic Acid Drugs for Prevention of Cardiac Rejection
Joint Authors
Morishita, Ryuichi
Isobe, Mitsuaki
Suzuki, Jun-ichi
Nagai, Ryozo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Heart transplantation has been broadly performed in humans.
However, occurrence of acute and chronic rejection has not yet been resolved.
Several inflammatory factors, such as cytokines and adhesion molecules, enhance the rejection.
The graft arterial disease (GAD), which is a type of chronic rejection, is characterized by intimal thickening comprised of proliferative smooth muscle cells.
Specific treatments that target the attenuation of acute rejection and GAD formation have not been well studied in cardiac transplantation.
Recent progress in the nucleic acid drugs, such as antisense oligodeoxynucleotides (ODNs) to regulate the transcription of disease-related genes, has important roles in therapeutic applications.
Transfection of cis-element double-stranded DNA, named as “decoy,” has been also reported to be a useful nucleic acid drug.
This decoy strategy has been not only a useful method for the experimental studies of gene regulation but also a novel clinical strategy.
In this paper, we reviewed the experimental results of NF-κB, E2F, AP-1, and STAT-1 decoy and other ODNs using the experimental heart transplant models.
American Psychological Association (APA)
Suzuki, Jun-ichi& Isobe, Mitsuaki& Morishita, Ryuichi& Nagai, Ryozo. 2009. Nucleic Acid Drugs for Prevention of Cardiac Rejection. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-507868
Modern Language Association (MLA)
Suzuki, Jun-ichi…[et al.]. Nucleic Acid Drugs for Prevention of Cardiac Rejection. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-507868
American Medical Association (AMA)
Suzuki, Jun-ichi& Isobe, Mitsuaki& Morishita, Ryuichi& Nagai, Ryozo. Nucleic Acid Drugs for Prevention of Cardiac Rejection. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-507868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507868