The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population
Joint Authors
Chiu, Yi-Ching
Hsu, Yu-Wen
Chang, Wei Chiao
Yang, Shengyu
Hou, Ming-Feng
Woon, Peng Yeong
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Breast cancer is the most common malignancy in women.
There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis.
Methods.
A total of 384 female patients with breast cancer were included in this study.
We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%.
Genotyping was performed using TaqMan allelic discrimination assay.
Chi-square (χ2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies.
Results.
Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model.
When the Bonferroni correction was performed, the significance still existed.
In addition, rs12320939 also associated with the lymph nodal involvement.
Conclusion.
We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.
American Psychological Association (APA)
Chang, Wei Chiao& Woon, Peng Yeong& Hsu, Yu-Wen& Yang, Shengyu& Chiu, Yi-Ching& Hou, Ming-Feng. 2012. The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507879
Modern Language Association (MLA)
Chang, Wei Chiao…[et al.]. The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-507879
American Medical Association (AMA)
Chang, Wei Chiao& Woon, Peng Yeong& Hsu, Yu-Wen& Yang, Shengyu& Chiu, Yi-Ching& Hou, Ming-Feng. The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-507879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507879