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Senescence-Accelerated Mice P8 : A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The causes of aging remain unknown, but they are probably intimately linked to a multifactorial process that affects cell networks to varying degrees.
Although a growing number of aging and Alzheimer’s disease (AD) animal models are available, a more comprehensive and physiological mouse model is required.
In this context, the senescence-accelerated mouse prone 8 (SAMP8) has a number of advantages, since its rapid physiological senescence means that it has about half the normal lifespan of a rodent.
In addition, according to data gathered over the last five years, some of its behavioral traits and histopathology resemble AD human dementia.
SAMP8 has remarkable pathological similarities to AD and may prove to be an excellent model for acquiring more in-depth knowledge of the age-related neurodegenerative processes behind brain senescence and AD in particular.
We review these facts and particularly the data on parameters related to neurodegeneration.
SAMP8 also shows signs of aging in the immune, vascular, and metabolic systems, among others.
American Psychological Association (APA)
Pallàs, Mercè. 2012. Senescence-Accelerated Mice P8 : A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-507930
Modern Language Association (MLA)
Pallàs, Mercè. Senescence-Accelerated Mice P8 : A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model. ISRN Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-507930
American Medical Association (AMA)
Pallàs, Mercè. Senescence-Accelerated Mice P8 : A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-507930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507930