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Target Gene and Function Prediction of Differentially Expressed MicroRNAs in Lactating Mammary Glands of Dairy Goats
Joint Authors
Ji, Zhi-Bin
Chen, Cun-Xian
Wang, Gui-Zhi
Dong, Fei
Wang, Jian-Min
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
MicroRNAs are small noncoding RNAs that can regulate gene expression, and they can be involved in the regulation of mammary gland development.
The differential expression of miRNAs during mammary gland development is expected to provide insight into their roles in regulating the homeostasis of mammary gland tissues.
To screen out miRNAs that should have important regulatory function in the development of mammary gland from miRNA expression profiles and to predict their function, in this study, the target genes of differentially expressed miRNAs in the lactating mammary glands of Laoshan dairy goats are predicted, and then the functions of these miRNAs are analyzed via bioinformatics.
First, we screen the expression patterns of 25 miRNAs that had shown significant differences during the different lactation stages in the mammary gland.
Then, these miRNAs are clustered according to their expression patterns.
Computational methods were used to obtain 215 target genes for 22 of these miRNAs.
Combining gene ontology annotation, Fisher’s exact test, and KEGG analysis with the target prediction for these miRNAs, the regulatory functions of miRNAs belonging to different clusters are predicted.
American Psychological Association (APA)
Dong, Fei& Ji, Zhi-Bin& Chen, Cun-Xian& Wang, Gui-Zhi& Wang, Jian-Min. 2013. Target Gene and Function Prediction of Differentially Expressed MicroRNAs in Lactating Mammary Glands of Dairy Goats. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-507946
Modern Language Association (MLA)
Dong, Fei…[et al.]. Target Gene and Function Prediction of Differentially Expressed MicroRNAs in Lactating Mammary Glands of Dairy Goats. International Journal of Genomics No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-507946
American Medical Association (AMA)
Dong, Fei& Ji, Zhi-Bin& Chen, Cun-Xian& Wang, Gui-Zhi& Wang, Jian-Min. Target Gene and Function Prediction of Differentially Expressed MicroRNAs in Lactating Mammary Glands of Dairy Goats. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-507946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507946