The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients
Joint Authors
Sachdeva, Mala
Kovalchuk, Oleksandr
Bitzer, Markus
Hung, Adriana
Mokrzycki, Michele H.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The contribution of the hemodialysis (HD) vascular access type to inflammation is unclear.
Methods.
We conducted a prospective observational study in an incident HD population.
C-reactive protein (CRP), interleukin-6 (IL-6), and interferon-γ-induced protein (IP-10) were measured before and at 6-time points after access placement for 1 year.
Results.
Sixty-four incident HD patients were included (tunneled catheter (TC), n=40, arteriovenous fistula (AVF), n=14, and arteriovenous graft (AVG), n=10).
A mixed effects model was performed to adjust for age, sex, race, coronary artery disease, diabetes mellitus, infections, access thrombosis, initiation of HD, and days after access surgery.
In comparison to AVFs, the presence of a TC was associated with significantly higher levels of CRP (P=0.03), IL-6 (P=0.07), and IP-10 (P=0.03).
The presence of an AVG was associated with increases in CRP (P=0.01) and IP-10 (P=0.07).
Conclusions.
Patients who initiate HD with a TC or an AVG have a heightened state of inflammation, which may contribute to the excess 90-day mortality after HD initiation.
American Psychological Association (APA)
Sachdeva, Mala& Hung, Adriana& Kovalchuk, Oleksandr& Bitzer, Markus& Mokrzycki, Michele H.. 2011. The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-507959
Modern Language Association (MLA)
Sachdeva, Mala…[et al.]. The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients. International Journal of Nephrology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-507959
American Medical Association (AMA)
Sachdeva, Mala& Hung, Adriana& Kovalchuk, Oleksandr& Bitzer, Markus& Mokrzycki, Michele H.. The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients. International Journal of Nephrology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-507959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507959