The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures
Joint Authors
Scheffer, Ingrid E.
Iona, Xenia
Mulley, John C.
Dibbens, Leanne M.
Heron, Sarah E.
Berkovic, Samuel F.
Hodgson, Bree
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Sixty cases of febrile seizures from a Chinese cohort had previously been reported with a strong association between variants in the seizure-related (SEZ) 6 gene and febrile seizures.
They found a striking lack of genetic variation in their controls.
We found genetic variation in SEZ6 at similar levels at the same DNA sequence positions in our 94 febrile seizure cases as in our 96 unaffected controls.
Two of our febrile seizure cases carried rare variants predicted to have damaging consequences.
Combined with some of the variants from the Chinese cohort, these data are compatible with a role for SEZ6 as a susceptibility gene for febrile seizures.
However, the polygenic determinants underlying most cases of febrile seizures with complex inheritance remain to be determined.
American Psychological Association (APA)
Mulley, John C.& Iona, Xenia& Hodgson, Bree& Heron, Sarah E.& Berkovic, Samuel F.& Scheffer, Ingrid E.…[et al.]. 2011. The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures. Neurology Research International،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-507970
Modern Language Association (MLA)
Mulley, John C.…[et al.]. The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures. Neurology Research International No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-507970
American Medical Association (AMA)
Mulley, John C.& Iona, Xenia& Hodgson, Bree& Heron, Sarah E.& Berkovic, Samuel F.& Scheffer, Ingrid E.…[et al.]. The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-507970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507970
