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Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation
Joint Authors
Sobrevia, Luis
Westermeier, Francisco
Villalobos-Labra, Roberto
Sáez, Pablo J.
Farías-Jofré, Marcelo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The global epidemics of obesity during pregnancy and excessive gestational weight gain (GWG) are major public health problems worldwide.
Obesity and excessive GWG are related to several maternal and fetal complications, including diabetes (pregestational and gestational diabetes) and intrauterine programming of insulin resistance (IR).
Maternal obesity (MO) and neonatal IR are associated with long-term development of obesity, diabetes mellitus, and increased global cardiovascular risk in the offspring.
Multiple mechanisms of insulin signaling pathway impairment have been described in obese individuals, involving complex interactions of chronically elevated inflammatory mediators, adipokines, and the critical role of the endoplasmic reticulum (ER) stress-dependent unfolded protein response (UPR).
However, the underlying cellular processes linking MO and IR in the offspring have not been fully elucidated.
Here, we summarize the state-of-the-art evidence supporting the possibility that adverse metabolic postnatal outcomes such as IR in the offspring of pregnancies with MO and/or excessive GWG may be related to intrauterine activation of ER stress response.
American Psychological Association (APA)
Westermeier, Francisco& Sáez, Pablo J.& Villalobos-Labra, Roberto& Sobrevia, Luis& Farías-Jofré, Marcelo. 2014. Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-507981
Modern Language Association (MLA)
Westermeier, Francisco…[et al.]. Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-507981
American Medical Association (AMA)
Westermeier, Francisco& Sáez, Pablo J.& Villalobos-Labra, Roberto& Sobrevia, Luis& Farías-Jofré, Marcelo. Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-507981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507981