Reduction of Monocyte Chemoattractant Protein-1 and Interleukin-8 Levels by Ticlopidine in TNF-α Stimulated Human Umbilical Vein Endothelial Cells
Joint Authors
Charoenfuprasert, Suparat
Hu, Chaur-Jong
Dai, Yu-Shan
Chang, Su-Mei
Tsai, Yu-Hui
Liu, Chia-Yu
Shih, Neng-Yao
Leu, Sy-Jye
Yang, Yi-Yuan
Lee, Yueh-Lun
Tseng, How
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Atherosclerosis and its associated complications represent major causes of morbidity and mortality in the industrialized or Western countries.
Monocyte chemoattractant protein-1 (MCP-1) is critical for the initiating and developing of atherosclerotic lesions.
Interleukin-8 (IL-8), a CXC chemokine, stimulates neutrophil chemotaxis.
Ticlopidine is one of the antiplatelet drugs used to prevent thrombus formation relevant to the pathophysiology of atherothrombosis.
In this study, we found that ticlopidine dose-dependently decreased the mRNA and protein levels of TNF-α-stimulated MCP-1, IL-8, and vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
Ticlopidine declined U937 cells adhesion and chemotaxis as compared to TNF-α stimulated alone.
Furthermore, the inhibitory effects were neither due to decreased HUVEC viability, nor through NF-kB inhibition.
These results suggest that ticlopidine decreased TNF-α induced MCP-1, IL-8, and VCAM-1 levels in HUVECs, and monocyte adhesion.
Therefore, the data provide additional therapeutic machinery of ticlopidine in treatment and prevention of atherosclerosis.
American Psychological Association (APA)
Hu, Chaur-Jong& Lee, Yueh-Lun& Shih, Neng-Yao& Yang, Yi-Yuan& Charoenfuprasert, Suparat& Dai, Yu-Shan…[et al.]. 2010. Reduction of Monocyte Chemoattractant Protein-1 and Interleukin-8 Levels by Ticlopidine in TNF-α Stimulated Human Umbilical Vein Endothelial Cells. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-507995
Modern Language Association (MLA)
Hu, Chaur-Jong…[et al.]. Reduction of Monocyte Chemoattractant Protein-1 and Interleukin-8 Levels by Ticlopidine in TNF-α Stimulated Human Umbilical Vein Endothelial Cells. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-507995
American Medical Association (AMA)
Hu, Chaur-Jong& Lee, Yueh-Lun& Shih, Neng-Yao& Yang, Yi-Yuan& Charoenfuprasert, Suparat& Dai, Yu-Shan…[et al.]. Reduction of Monocyte Chemoattractant Protein-1 and Interleukin-8 Levels by Ticlopidine in TNF-α Stimulated Human Umbilical Vein Endothelial Cells. Journal of Biomedicine and Biotechnology. 2010. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-507995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507995