Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh
Joint Authors
Guzman, Grace
Wojewoda, Christina
Layden, Thomas J.
Berkes, Jamie
Chennuri, Rohini
Cotler, Scott J.
Kallwitz, Eric R.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There are a growing number of cases detailing acute hepatic necrosis in patients taking black cohosh (Cimicifuga racemosa), an over-the-counter herbal supplement for management of menopausal symptoms.
Our aim is to illustrate two cases of liver injury following the use of black cohosh characterized by histopathological features mimicking autoimmune hepatitis.
Both patients reported black cohosh use for at least six months and had no evidence of another cause of liver disease.
Their liver biopsies showed a component of centrilobular necrosis consistent with severe drug-induced liver injury.
In addition, the biopsies showed characteristics of autoimmune-like liver injury with an interface hepatitis dominated by plasma cells.
Although serum markers for autoimmune hepatitis were not particularly elevated, both patients responded to corticosteroids, supporting an immune-mediated component to the liver injury.
Liver injury following the use of black cohosh should be included in the list of differential diagnoses for chronic hepatitis with features mimicking autoimmune hepatitis.
American Psychological Association (APA)
Guzman, Grace& Kallwitz, Eric R.& Wojewoda, Christina& Chennuri, Rohini& Berkes, Jamie& Layden, Thomas J.…[et al.]. 2010. Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh. Case Reports in Medicine،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-508035
Modern Language Association (MLA)
Guzman, Grace…[et al.]. Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh. Case Reports in Medicine No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-508035
American Medical Association (AMA)
Guzman, Grace& Kallwitz, Eric R.& Wojewoda, Christina& Chennuri, Rohini& Berkes, Jamie& Layden, Thomas J.…[et al.]. Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh. Case Reports in Medicine. 2010. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-508035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508035