The E3 Ligase CHIP : Insights into Its Structure and Regulation
Joint Authors
Ghosh, Mrinal Kanti
Paul, Indranil
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The carboxy-terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase containing three tandem repeats of tetratricopeptide (TPR) motifs and a C-terminal U-box domain separated by a charged coiled-coil region.
CHIP is known to function as a central quality control E3 ligase and regulates several proteins involved in a myriad of physiological and pathological processes.
Recent studies have highlighted varied regulatory mechanisms operating on the activity of CHIP which is crucial for cellular homeostasis.
In this review article, we give a concise account of our current knowledge on the biochemistry and regulation of CHIP.
American Psychological Association (APA)
Paul, Indranil& Ghosh, Mrinal Kanti. 2014. The E3 Ligase CHIP : Insights into Its Structure and Regulation. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-508037
Modern Language Association (MLA)
Paul, Indranil& Ghosh, Mrinal Kanti. The E3 Ligase CHIP : Insights into Its Structure and Regulation. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-508037
American Medical Association (AMA)
Paul, Indranil& Ghosh, Mrinal Kanti. The E3 Ligase CHIP : Insights into Its Structure and Regulation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-508037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508037