Endothelial Dysfunction and Diabetes : Effects on Angiogenesis, Vascular Remodeling, and Wound Healing
Joint Authors
Kolluru, Gopi Krishna
Kevil, Christopher G.
Bir, Shyamal C.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia due to lack of or resistance to insulin.
Patients with DM are frequently afflicted with ischemic vascular disease or wound healing defect.
It is well known that type 2 DM causes amplification of the atherosclerotic process, endothelial cell dysfunction, glycosylation of extracellular matrix proteins, and vascular denervation.
These complications ultimately lead to impairment of neovascularization and diabetic wound healing.
Therapeutic angiogenesis remains an attractive treatment modality for chronic ischemic disorders including PAD and/or diabetic wound healing.
Many experimental studies have identified better approaches for diabetic cardiovascular complications, however, successful clinical translation has been limited possibly due to the narrow therapeutic targets of these agents or the lack of rigorous evaluation of pathology and therapeutic mechanisms in experimental models of disease.
This paper discusses the current body of evidence identifying endothelial dysfunction and impaired angiogenesis during diabetes.
American Psychological Association (APA)
Kolluru, Gopi Krishna& Bir, Shyamal C.& Kevil, Christopher G.. 2012. Endothelial Dysfunction and Diabetes : Effects on Angiogenesis, Vascular Remodeling, and Wound Healing. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-30.
https://search.emarefa.net/detail/BIM-508044
Modern Language Association (MLA)
Kolluru, Gopi Krishna…[et al.]. Endothelial Dysfunction and Diabetes : Effects on Angiogenesis, Vascular Remodeling, and Wound Healing. International Journal of Vascular Medicine No. 2012 (2012), pp.1-30.
https://search.emarefa.net/detail/BIM-508044
American Medical Association (AMA)
Kolluru, Gopi Krishna& Bir, Shyamal C.& Kevil, Christopher G.. Endothelial Dysfunction and Diabetes : Effects on Angiogenesis, Vascular Remodeling, and Wound Healing. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-30.
https://search.emarefa.net/detail/BIM-508044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508044