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von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes
Joint Authors
Vuletic, Milena S.
Barudzic, Nevena S.
Andjelkovic, Nebojsa
Krkeljic, Jelena
Iric-Cupic, Violeta
Koprivica, Zoran
Jakovljevic, Vladimir Lj.
Djuric, Dragan M.
Zivkovic, Vladimir I.
Djordjevic, Dusica Z.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS).
Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites–NO2 −), superoxide anion radical (O2 −), hydrogen peroxide (H2O2), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances–TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls.
ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO2 −, H2O2, SOD and CAT activities were lower than controls'.
vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects.
Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type.
The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence.
American Psychological Association (APA)
Koprivica, Zoran& Djordjevic, Dusica Z.& Vuletic, Milena S.& Zivkovic, Vladimir I.& Barudzic, Nevena S.& Andjelkovic, Nebojsa…[et al.]. 2011. von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-508055
Modern Language Association (MLA)
Koprivica, Zoran…[et al.]. von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-508055
American Medical Association (AMA)
Koprivica, Zoran& Djordjevic, Dusica Z.& Vuletic, Milena S.& Zivkovic, Vladimir I.& Barudzic, Nevena S.& Andjelkovic, Nebojsa…[et al.]. von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-508055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508055