Tumor Evasion from T Cell Surveillance
Joint Authors
Cartellieri, Marc
Schmitz, Marc
Bachmann, Michael
Schackert, Gabriele
Töpfer, Katrin
Müller, Nadja
Kempe, Stefanie
Temme, Achim
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
An intact immune system is essential to prevent the development and progression of neoplastic cells in a process termed immune surveillance.
During this process the innate and the adaptive immune systems closely cooperate and especially T cells play an important role to detect and eliminate tumor cells.
Due to the mechanism of central tolerance the frequency of T cells displaying appropriate arranged tumor-peptide-specific-T-cell receptors is very low and their activation by professional antigen-presenting cells, such as dendritic cells, is frequently hampered by insufficient costimulation resulting in peripheral tolerance.
In addition, inhibitory immune circuits can impair an efficient antitumoral response of reactive T cells.
It also has been demonstrated that large tumor burden can promote a state of immunosuppression that in turn can facilitate neoplastic progression.
Moreover, tumor cells, which mostly are genetically instable, can gain rescue mechanisms which further impair immune surveillance by T cells.
Herein, we summarize the data on how tumor cells evade T-cell immune surveillance with the focus on solid tumors and describe approaches to improve anticancer capacity of T cells.
American Psychological Association (APA)
Töpfer, Katrin& Kempe, Stefanie& Müller, Nadja& Schmitz, Marc& Bachmann, Michael& Cartellieri, Marc…[et al.]. 2011. Tumor Evasion from T Cell Surveillance. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-508081
Modern Language Association (MLA)
Töpfer, Katrin…[et al.]. Tumor Evasion from T Cell Surveillance. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-508081
American Medical Association (AMA)
Töpfer, Katrin& Kempe, Stefanie& Müller, Nadja& Schmitz, Marc& Bachmann, Michael& Cartellieri, Marc…[et al.]. Tumor Evasion from T Cell Surveillance. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-508081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508081