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Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer’s Disease?
Joint Authors
Sabbagh, Marwan N.
Lue, Lih-Fen
Walker, Douglas
Andrade, Cassandra
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metabolic dysregulation, including abnormal glucose utilization and insulin resistance or deficiency, occurs at an early stage of AD independent of type II diabetes mellitus (T2DM).
Thus, AD has been considered as type 3 diabetes.
T2DM is a risk factor for AD; the coexistence of these two diseases in a society with an increasing mean age is a significant issue.
Recently, research has focused on shared molecular mechanisms in these two diseases with the goal of determining whether treating T2DM can lessen the severity of AD.
The progress in this field lends strong support to several mechanisms that could affect these two diseases, including insulin resistance and signaling, vascular injuries, inflammation, and the receptor for advanced glycation endproducts and their ligands.
In this paper, we focus on inflammation-based mechanisms in both diseases and discuss potential synergism in these mechanisms when these two diseases coexist in the same patient.
American Psychological Association (APA)
Lue, Lih-Fen& Andrade, Cassandra& Sabbagh, Marwan N.& Walker, Douglas. 2012. Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer’s Disease?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-508094
Modern Language Association (MLA)
Lue, Lih-Fen…[et al.]. Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer’s Disease?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-508094
American Medical Association (AMA)
Lue, Lih-Fen& Andrade, Cassandra& Sabbagh, Marwan N.& Walker, Douglas. Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer’s Disease?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-508094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508094