Pharmacokinetics of PEGylated Recombinant Human Erythropoietin in Rats
Joint Authors
Ge, Yonghong
Zeng, Xianyin
Chen, Zhiyong
Cao, Xiaohan
Yu, Zhuoran
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
rHuEPO plays a central role as chemicals for the treatment of many diseases.
Due to its short half-life, the main aim for this pharmacokinetic study is to investigate a newly developed PEG-rHuEPO with large molecular weight in SD rats.
After a single intramuscular administration of different doses of 125I-PEG-rHuEPO, pharmacokinetic parameters, tissue distribution, and excretion were analyzed.
In in vivo half-life time measured after 125I-PEG-rHuEPO administration at the doses of 1, 2, and 3 μg/kg, t1/2α was 1.90, 1.19, and 2.50 hours, respectively, whereas t1/2β was 22.37, 26.21, and 20.92 hours, respectively; at 8, 24, and 48 hours after intramuscular administration, PEG-rHuEPO was distributed to all of the examined tissues, however, with high concentrations of radioactivity, only in plasma, blood, muscle at the administration site, and bone marrow.
Following a 2 μg/kg single intramuscular administration, approximately 21% of the radiolabeled dose was recovered after almost seven days of study.
Urine was the major route of excretion; 20% of the administered dose was recovered in the urine, while excretion in the feces was less than 1.4%.
Therefore, this PEG-rHuEPO has potential to be clinically used and could reduce frequency of injection.
American Psychological Association (APA)
Cao, Xiaohan& Chen, Zhiyong& Yu, Zhuoran& Ge, Yonghong& Zeng, Xianyin. 2014. Pharmacokinetics of PEGylated Recombinant Human Erythropoietin in Rats. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-508095
Modern Language Association (MLA)
Cao, Xiaohan…[et al.]. Pharmacokinetics of PEGylated Recombinant Human Erythropoietin in Rats. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-508095
American Medical Association (AMA)
Cao, Xiaohan& Chen, Zhiyong& Yu, Zhuoran& Ge, Yonghong& Zeng, Xianyin. Pharmacokinetics of PEGylated Recombinant Human Erythropoietin in Rats. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-508095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508095