New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer
Joint Authors
Njar, Vincent C. O.
Godbole, Abhijit M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Prostate cancer is the most common cancer in men in the United States, and it is the second leading cause of cancer-related death in American men.
The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease.
While most efforts in the clinic are currently directed at lowering levels of androgens that activate AR, resistance to androgen deprivation eventually develops.
Most prostate cancer deaths are attributable to this castration-resistant form of prostate cancer (CRPC).
Recent work has shed light on the importance of epigenetic events including facilitation of AR signaling by histone-modifying enzymes, posttranslational modifications of AR such as sumoylation.
Herein, we provide an overview of the structure of human AR and its key structural domains that can be used as targets to develop novel antiandrogens.
We also summarize recent findings about the antiandrogens and the epigenetic factors that modulate the action of AR.
American Psychological Association (APA)
Godbole, Abhijit M.& Njar, Vincent C. O.. 2011. New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer. Prostate Cancer،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-508096
Modern Language Association (MLA)
Godbole, Abhijit M.& Njar, Vincent C. O.. New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer. Prostate Cancer No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-508096
American Medical Association (AMA)
Godbole, Abhijit M.& Njar, Vincent C. O.. New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer. Prostate Cancer. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-508096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508096